NFL Odds: How To Bet Colts Against 49ers, Point Spread, More

Sagging San Francisco 49ers hope a week off hope helps them break a three-game slippage as they face the Indianapolis Colts on Sunday.

Here’s everything you need to know about the NFL odds in Sunday’s Colts-49ers game – the point spread, silver line, total over / under, and our betting expert’s pick. (with all NFL odds via FOX Bet).


Point of deviation: 49ers -4 (the favorite 49ers to win by more than 4 points, otherwise the Colts cover)
Moneyline: 49ers -200 favorites to win (bet $ 10 to win $ 15 in total); Colts +170 underdogs up for grabs (bet $ 10 to win $ 27 total)
Total score above / below: 44.5 points scored by both teams combined

The Colts hold a 26-19 all-time series lead, with Indianapolis winning the last four games, the most recent of which was a 26-23 overtime victory at home on October 8, 2017.

Ahead of the Colts’ four-game winning streak, the 49ers beat the Colts seven times in eight games.

The 49ers are 0-6 at home since last season.

It looks like Jimmy Garoppolo is returning to the 49ers quarterback, replacing rookie Trey Lance.

Garoppolo suffered a calf injury in early October and missed the last six quarters, but has been in training this week and coach Kyle Shanahan has said he’s optimistic Garoppolo will play. Lance, the third overall pick for North Dakota State in April, sprained his knee in Sunday’s game and his status is unknown for the Colts game.

In his first NFL start on Sunday against Arizona, Lance was 15 for 29 passes for 192 yards and an interception. Lance also ran 89 yards on 16 attempts, the highest by a 49ers quarterback in a game since Colin Kaepernick rushed for 113 yards on 10 carries against the Dolphins in 2016.

Garoppolo has missed 24 of 53 starts since the 49ers made him the league’s highest-paid player heading into the 2018 season.

Indianapolis’ Carson Wentz is 124 for 193 passes (64.2 percent of passes completed) for 1,545 yards (257.5 per game) this season. He threw nine touchdowns with one interception.

“I like the Colts here. Carson Wentz is playing well,” said Colin Cowherd of FOX Sports. “He now has several games without interceptions and three touchdowns. Protection has also improved and Jonathan Taylor is a star.

“The Colts are healthier and Wentz is getting more comfortable. He plays very smart football and limits turnovers under Frank Reich. By the way, they did the same together in Philly.”

The Colts have averaged 18.7 points per game in their first three games and 27.7 points in their last three games.

Turnover could be a key in this game. The Colts forced 12 turnovers, the fourth best in the NFL. The 49ers forced two turnovers, 31st in the NFL.

San Francisco and its opponent have accumulated more than 44 points three times this season.

The Colts are 2-4 and the 49ers 2-3 against the silver line this season.

Indianapolis ATS record is 4-2.

San Francisco has scored more than twice in five games while Indianapolis has scored more than three times in six games.

The 49ers have two takeaways, tied for league worst with the Jaguars.

Click here for the latest NFL odds on and the FOX Sports app for everything you need in the world of sports betting.

Choose via Colin Cowherd of FOX Sports: “It’s one of my best bets on the board. The best quarterback won 13 of 13 games last weekend. Carson Wentz with Frank Reich is the best quarterback in this game.”

TO TAKE: Colts (+4 at FOX Bet) will lose by less than 3.5 points or win outright

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